Polyamine inhibitors

Influence of Inhibitors of Polyamine Biosynthesis on Polyamine Levels and Growth of Plants

Z. Naturforsch. 44c, 55 — 58 (1989); received August 1, 1988 Abutilon theophrasti, Lycopersicon esculentum, S-Adenosylmethionine Decarboxylase, Arginine Decarboxylase. Ornithine Decarboxylase, Spermidine Synthase Inhibitors of enzymes involved in polyamine biosynthesis which stop the growth of bacteria, fungi and animal cell systems were analyzed for their potential to interfere with plant cell...

Delayed Sensitizaron to Heat by Inhibitors of Polyamine-biosynthetic Enzymes1

Exposure of Chinese hamster ovary cells to the enzyme inhibitors methylglyoxal bis(guanylhydrazone and a-difluoromethylornithine (DFMO) results in increased sensitivity to hyperthermia. While methylglyoxal bis(guanylhydrazone) dem onstrates pronounced cytotoxicity at moderate extracellular concentrations, DFMO is tolerated well by this cell line at concentrations of up to 10 mw, as assayed by c...

Polyamine-Polyamine and Polyamine-Protein Transport Inhibitor Conjugates and Their Use as Pharmaceuticals and in Research Relating to Polyamine Transport

Inhibitors of Polyamine Biosynthesis Block Tumor Necrosis Factor-induced Activation of Macrophages1

The activation of polyamine biosynthesis, dependent on increased gene expression of ornithine decarboxylase, has been found to play an impor tant role in the control of cell proliferation and differentiation. In this report it has been found that accumulation of ornithine decarboxylase mRNA also follows stimulation of human monocytes/macrophages by tumor necrosis factor. Human recombinant tumor...

Glucocorticoids and polyamine inhibitors synergize to kill human leukemic CEM cells.

Glucocorticoids are well-known apoptotic agents in certain classes of lymphoid cell malignancies. Reduction of intracellular polyamine levels by use of inhibitors that block polyamine synthesis slows or inhibits growth of many cells in vitro. Several such inhibitors have shown efficacy in clinical trials, though the toxicity of some compounds has limited their usefulness. We have tested the eff...